Synthesis of Novel 1,3-Indandione Derivatives and Investigation Their Anti-Microbial and Anti-Fungal Activity

Abstract

1,3 -Indanedione derivatives, which are of wide interest because of their diverse biological and chemical applications. A series of novel 1,3-Indanedione derivatives are synthesized via KNOEVENAGEL condensing reaction mechanism by condensing 1,3-Indanedione with diverse aryl aldehydes using2-hydroxyethyammonium formate as ionic liquid and catalyst. All the synthetic derivatives were fully characterized by spectral analysis data (FT-IR, 1H- 13C-NMR and elemental analysis).

This series of 7 compounds were tested for in vitro anti-bacterial activity against Gram- negative Escherichia coli ATCC 25922 and Proteus mirabilis ATCC 43071, Gram–positive Staphylococcus aureus ATCC 25952 and Enterococcus faecalis ATCC 29212. Anti-fungal activity of the newly synthesized derivatives was evaluated by Disc diffusion method with Candida albicans. The newly synthesized compounds are evaluated for their antimicrobial activity (by using Cup- Plate method against selected bacterial strains among total compounds, compounds 7 was found to have higher activity against selected strains and the results were found to be as moderate activity, for anti-fungal activity-compounds 2,5 are more potent .